Selected Publications of our scientific advisors:

Structural basis for the function and inhibition of an influenza virus proton channel. Nature 2008, 451, 596-600

(Stouffer, A. L., Acharya, R., Salom, D., Levine, A. S., Di Costanzo, L.,Soto, C. S., Tereshko, V., Nanda, V., Stayrook, S. & DeGrado, W. F.)

Structure of the amantadine binding site of influenza M2 proton channels in lipid bilayers, Nature, 2010, 463(7281):689-92

(Cady, SD, Schmidt-Rohr, K, Wang, J., Soto, C., DeGrado, WF & Hong, M.)

Structure and mechanism of proton transport through the transmembrane tetrameric M2 protein bundle of the influenza A virus. Proc. Natl Acad Sci USA 2010, 107 (34):15075

(Acharya R, Carnevale V, Fiorin G, Levine BG, Polishchuk AL, Balannik V, Samish I, Lamb RA, Pinto LH, DeGrado WF, Klein ML.)

Functional studies and modeling of pore-lining residue mutants of the influenza a virus M2 ion channel. Biochemistry 2010, 49 (4):696-708

(Balannik V, Carnevale V, Fiorin G, Levine BG, Lamb RA, Klein ML, DeGrado WF, Pinto LH)

Specific binding of adamantane drugs and direction of their polar amines in the pore of the influenza M2 transmembrane domain in lipid bilayers and dodecylphosphocholine micelles determined by NMR spectroscopy. J. Am. Chem. Soc. 2011, 133(12):4274-84

(Cady, S.D., Wang, J., Wu, Y., DeGrado, W.F., Hong, M.)

Structural and dynamic mechanisms for the function and inhibition of the M2 proton channel from influenza A virus. Current Opinion in Structural Biology 2011, 21:68–80

(Wang, J., Qiu, J.X., Soto, C., DeGrado, W.F.)

Exploring the requirements for the hydrophobic scaffold and polar amine in inhibitors of M2 from influenza A virus. ACS Med. Chem. Lett. 2011, 2 (4), 307–312

(Wang, J., Ma, C., Balannik, V., Pinto, L. H., Lamb, R. A., and DeGrado, W. F.)

Proton and cation transport activity of the M2 proton channel from influenza A virus, Proc. Natl. Acad. Sci. U.S.A. 2010, 107, 15409-15414

(Leiding, T., Wang, J., Martinsson, J., DeGrado, W. F., and Arskold, S. P)